Suzuki Jun, Hashimoto Sho, Watanabe Ken-ichi, Takahashi Kaoru, Usubuchi Hajime, Suzuki Hiroyoshi
Department of Otolaryngology, National Sendai Medical Center, 2-8-8 Miyagino, Miyagino-ku, Sendai, Miyagi 983-8520, Japan.
Auris Nasus Larynx. 2012 Jun;39(3):321-5. doi: 10.1016/j.anl.2011.06.004. Epub 2011 Sep 8.
Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. Complete resection with a safety margin is essential because of the tendency for local invasion.
漏斗状癌（CC）是低级别鳞状细胞癌（SCC）的一种罕见变体，在口腔中发生极为罕见。CC具有类似疣状癌的乳头状角化表面，但CC有局部侵袭性生长的倾向，尤其是侵犯骨质。因此，CC手术切除可能相当困难。一名68岁男性患者，下颌牙龈出现类似疣状白斑的CC病例。多次活检均未发现恶性病变。进行了局部切除，组织学检查显示为高分化SCC。随后进行了额外的半侧下颌骨切除术，最终组织学诊断为CC。在14个月的随访检查中发现局部复发。多西他赛化疗无效，患者死于吸入性肺炎。口腔CC是一种罕见疾病，诊断难以确立。误诊可能导致切除不彻底和局部复发。由于其局部侵袭倾向，进行有安全切缘的完整切除至关重要。
