口腔漏斗状癌：口腔鳞状细胞癌临床病理谱系中的一种新实体。
Oral Carcinoma Cuniculatum: A New Entity in the Clinicopathological Spectrum of Oral Squamous Cell Carcinoma.
作者信息
Datar Uma Vasant, Kale Alka, Mane Deepa
机构信息
Assistant Professor, Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
Professor, Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences , Belgaum, Karnataka, India .
出版信息
J Clin Diagn Res. 2017 Jan;11(1):ZD37-ZD39. doi: 10.7860/JCDR/2017/23437.9226. Epub 2017 Jan 1.
Carcinoma cuniculatum is principally recognized as a variant of carcinoma involving foot. The World Health Organization (WHO) recognizes Oral Carcinoma Cuniculatum (OCC) as a distinct and rare clinicopathological variant of Oral Squamous Cell Carcinoma (OSCC). OCC is confused clinically and histologically with Verrucous Carcinoma (VC) and is often misdiagnosed as either VC or OSCC. To best of our knowledge, till date, only 50 cases of this tumour have been reported in oral cavity (including the present case) and only limited number of cases have been reported from Indian subcontinent. Pathognomonic feature of OCC is proliferation of stratified squamous epithelium and its infiltration into underlying stroma forming a complex pattern of keratin cores and keratin filled crypts. These complex crypts give it a likeness of rabbit burrow hence, the name cuniculatum (cuniculatus='rabbit warren'). The report aims to present a case of OCC of mandibular gingiva, discuss its diagnostic features and highlight its differences from VC and OSCC.
漏斗状癌主要被认为是累及足部的一种癌变体。世界卫生组织（WHO）将口腔漏斗状癌（OCC）认定为口腔鳞状细胞癌（OSCC）一种独特且罕见的临床病理变体。OCC在临床和组织学上与疣状癌（VC）混淆，常被误诊为VC或OSCC。据我们所知，截至目前，口腔内仅报道过50例这种肿瘤（包括本病例），印度次大陆报道的病例数量有限。OCC的特征性表现是复层鳞状上皮增生并浸润至下方基质，形成角质核心和充满角蛋白的隐窝的复杂模式。这些复杂的隐窝使其形似兔穴，因此得名漏斗状（cuniculatus意为“兔穴”）。本报告旨在呈现一例下颌牙龈OCC病例，讨论其诊断特征，并突出其与VC和OSCC的差异。
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