Department of Chemical and Biological Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ J08544, USA.
Curr Opin Genet Dev. 2011 Dec;21(6):719-25. doi: 10.1016/j.gde.2011.07.009. Epub 2011 Aug 19.
Spatial patterns of cell differentiation in developing tissues can be controlled by receptor tyrosine kinase (RTK) signaling gradients, which may form when locally secreted ligands activate uniformly expressed receptors. Graded activation of RTKs can span multiple cell diameters, giving rise to spatiotemporal patterns of signaling through the Extracellular Signal Regulated/Mitogen Activated Protein Kinase (ERK/MAPK), which connects receptor activation to multiple aspects of tissue morphogenesis. This general mechanism has been identified in numerous developmental contexts, from body axis specification in insects to patterning of the mammalian neocortex. We review recent quantitative studies of this mechanism in Drosophila oogenesis, an established genetic model of signaling through the Epidermal Growth Factor Receptor (EGFR), a highly conserved RTK.
发育组织中细胞分化的空间模式可受受体酪氨酸激酶 (RTK) 信号梯度控制，当局部分泌的配体激活均匀表达的受体时，可能会形成这种信号梯度。RTK 的分级激活可以跨越多个细胞直径，通过细胞外信号调节/有丝分裂原激活蛋白激酶 (ERK/MAPK) 产生信号的时空模式，ERK/MAPK 将受体激活与组织形态发生的多个方面联系起来。这种通用机制已在许多发育背景中得到鉴定，从昆虫的体轴特化到哺乳动物新皮层的模式形成。我们回顾了最近在果蝇卵子发生中对这种机制的定量研究，卵子发生是通过高度保守的 RTK 表皮生长因子受体 (EGFR) 进行信号转导的经典遗传模型。
