Yakoby N, Bristow C A, Gouzman I, Rossi M P, Gogotsi Y, Schüpbach T, Shvartsman S Y
Lewis-Sigler Institute for Integrative Genomics and Department of Chemical Engineering, Princeton University, USA.
Syst Biol (Stevenage). 2005 Dec;152(4):276-84. doi: 10.1049/ip-syb:20050039.
This paper describes computational and experimental work on pattern formation in Drosophila egg development (oogenesis), an established experimental model for studying cell fate diversification in developing tissues. Epidermal growth factor receptor (EGFR) is a key regulator of pattern formation and morphogenesis in Drosophila oogenesis. EGFR signalling in oogenesis can be genetically manipulated and monitored at many levels, leading to large sets of heterogeneous data that enable the formulation of increasingly quantitative models of pattern formation in these systems.
本文描述了关于果蝇卵子发育（卵子发生）中模式形成的计算和实验工作，果蝇卵子发育是研究发育组织中细胞命运多样化的一个成熟实验模型。表皮生长因子受体（EGFR）是果蝇卵子发生中模式形成和形态发生的关键调节因子。卵子发生中的EGFR信号传导可以在多个层面进行基因操作和监测，从而产生大量异质性数据，这些数据有助于构建这些系统中模式形成的越来越定量的模型。
