光动力疗法治疗义齿性口炎：5例报告
Denture stomatitis treated with photodynamic therapy: five cases.
作者信息
Mima Ewerton Garcia de Oliveira, Pavarina Ana Cláudia, Silva Mariana Montenegro, Ribeiro Daniela Garcia, Vergani Carlos Eduardo, Kurachi Cristina, Bagnato Vanderlei Salvador
机构信息
Dentistry School, São Francisco University, Bragança Paulista, São Paulo, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Nov;112(5):602-8. doi: 10.1016/j.tripleo.2011.05.019. Epub 2011 Sep 8.
OBJECTIVE
Photodynamic therapy (PDT) is an effective method for Candida spp. inactivation in vitro and in vivo, but as yet, no clinical trial has been conducted. This report describes 5 cases of denture stomatitis (DS) treated with PDT.
STUDY DESIGN
Five subjects with clinical and microbiologic diagnosis of DS were submitted to 6 sessions of PDT 3 times a week for 15 days. In each session, patients' dentures and palates were sprayed with 500 mg/L Photogem, and, after 30 minutes of incubation, irradiated by light-emitting diode light source at 455 nm (37.5 and 122 J/cm(2), respectively). Cultures of Candida spp. from dentures and palates and standard photographs of the palates were taken at baseline (day 0), at the end of the treatment (day 15), and at follow-up time intervals (days 30 and 60).
RESULTS
Four patients showed clinical resolution of DS (no inflammation) after PDT sessions, and only 1 subject demonstrated reduction in palatal inflammation. Recurrence of DS was observed in 2 patients during the follow-up period.
CONCLUSIONS
PDT appears to be an alternative treatment for DS.
目的
光动力疗法（PDT）是一种在体外和体内使念珠菌属失活的有效方法，但迄今为止尚未进行临床试验。本报告描述了5例接受PDT治疗的义齿性口炎（DS）病例。
研究设计
5名经临床和微生物学诊断为DS的受试者，每周接受3次，共6次PDT治疗，持续15天。每次治疗时，用500mg/L的光动力剂（Photogem）喷洒患者的义齿和腭部，孵育30分钟后，用455nm的发光二极管光源照射（分别为37.5和122J/cm²）。在基线（第0天）、治疗结束时（第15天）以及随访时间间隔（第30天和第60天）采集义齿和腭部的念珠菌属培养物以及腭部的标准照片。
结果
4例患者在PDT治疗后DS临床症状消失（无炎症），只有1例患者腭部炎症减轻。在随访期间，2例患者出现DS复发。
结论
PDT似乎是DS的一种替代治疗方法。
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