Ziental Daniel, Mlynarczyk Dariusz T, Czarczynska-Goslinska Beata, Lewandowski Konrad, Sobotta Lukasz
Chair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Nanomaterials (Basel). 2021 Oct 28;11(11):2883. doi: 10.3390/nano11112883.
Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.
浅表和全身性真菌感染是现代医疗保健系统面临的重要问题。挑战之一是真菌对传统抗真菌药物的耐药性不断增强，以及治疗成本持续上升。这些因素促使科学界加紧寻找替代的、更有效的治疗方法。本文概述了使用光动力抗菌化学疗法（PACT）的新型真菌灭活方法。介绍了对吩噻嗪类、呫吨类、卟啉类、二氢卟吩类、卟啉嗪类和酞菁类化合物的研究结果。目前正在大力寻找具有优异性能的光敏剂。还通过将现有配方与纳米颗粒和常规抗真菌疗法相结合来开发基于现有配方的制剂。大量研究表明，真菌不会对PACT形成任何特定的防御机制，这使其成为一种有前景的治疗选择。
