Snf2 家族蛋白：万变不离其宗的染色质重塑因子
Snf2-family proteins: chromatin remodellers for any occasion.
机构信息
Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, DD1 5EH, UK.
出版信息
Curr Opin Chem Biol. 2011 Oct;15(5):649-56. doi: 10.1016/j.cbpa.2011.07.022. Epub 2011 Aug 20.
Abstract
Chromatin facilitates the housing of eukaryotic DNA within the nucleus and restricts access to the underlying sequences. Thus, the regulation of chromatin structure provides an excellent platform for regulating processes that require information stored within genomic DNA. Snf2 proteins are a family of helicase-like proteins that direct energy derived from ATP hydrolysis into the mechanical remodelling of chromatin structure. Here, we highlight some of the recent discoveries regarding this family of proteins and show Snf2 proteins have roles in many aspects of genetic metabolism. Recent developments include new insights into the mechanism for nucleosome spacing and histone dimer exchange; together with growing evidence for the involvement of Snf2 proteins in DNA repair.
摘要
染色质将真核生物的 DNA 固定在细胞核内，并限制了对其底层序列的访问。因此，染色质结构的调控为调节需要基因组 DNA 中存储的信息的过程提供了一个极好的平台。Snf2 蛋白是一类螺旋酶样蛋白，它们将源自 ATP 水解的能量引导到染色质结构的机械重塑中。在这里，我们强调了这个蛋白家族的一些最新发现，并表明 Snf2 蛋白在遗传代谢的许多方面都发挥了作用。最近的进展包括对核小体间隔和组蛋白二聚体交换机制的新见解；以及越来越多的证据表明 Snf2 蛋白参与 DNA 修复。
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