好与恶的环：RING 指泛素连接酶在肿瘤抑制和致癌作用中的十字路口。
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis.
机构信息
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
出版信息
Nat Rev Cancer. 2011 Aug 24;11(9):629-43. doi: 10.1038/nrc3120.
Abstract
The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area.
摘要
泛素-蛋白酶体系统在生理和病理生理学中具有许多重要作用。该系统的特异性的基础是泛素-蛋白连接酶（E3s）。其中，大多数是环指和环指相关的 E3s。许多环指 E3s 在维持基因组完整性和细胞内稳态的过程中发挥作用，例如促进有丝分裂后期复合物/周期蛋白（APC/C）、SKP1-cullin 1-F-box 蛋白（SCF）E3s、MDM2、BRCA1、范可尼贫血蛋白、CBL 蛋白、von Hippel-Lindau 肿瘤抑制因子（VHL）和 SIAH 蛋白。因此，许多环指 E3s 参与癌症的抑制或进展。这篇综述总结了这一领域的最新知识。
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