Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
Nat Rev Cancer. 2011 Aug 24;11(9):629-43. doi: 10.1038/nrc3120.
The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area.
泛素-蛋白酶体系统在生理和病理生理学中具有许多重要作用。该系统的特异性的基础是泛素-蛋白连接酶（E3s）。其中，大多数是环指和环指相关的 E3s。许多环指 E3s 在维持基因组完整性和细胞内稳态的过程中发挥作用，例如促进有丝分裂后期复合物/周期蛋白（APC/C）、SKP1-cullin 1-F-box 蛋白（SCF）E3s、MDM2、BRCA1、范可尼贫血蛋白、CBL 蛋白、von Hippel-Lindau 肿瘤抑制因子（VHL）和 SIAH 蛋白。因此，许多环指 E3s 参与癌症的抑制或进展。这篇综述总结了这一领域的最新知识。
