Birt D F
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
Nutr Rev. 1990 Jan;48(1):1-5. doi: 10.1111/j.1753-4887.1990.tb02870.x.
Recent studies of the effects of dietary fat on experimental carcinogenesis have probed the influence of the dietary fat source, the time during carcinogenesis when a high-fat diet is fed, the interactions between fat and calories, and the potential mechanisms for the observed effects of fat on cancer. The essential fatty acids in the fat, the degree of their unsaturation, and the location of the unsaturation are all important in determining the influence of a dietary fat source on carcinogenesis. In addition, alterations in dietary fat can modify various sites and forms of cancer differently. Dietary fat has been clearly shown to be important in the promotion of cancer, and recent studies indicate that dietary fat can also be a factor in the initiation of cancer. Although the calories contributed by a high-fat diet also factor into cancer enhancement, dietary fat appears to contribute more than its high-caloric density. One potential mechanism for the influence of dietary fat on carcinogenesis is through modulating the activation of protein kinase C.
近期关于膳食脂肪对实验性致癌作用影响的研究，探讨了膳食脂肪来源的影响、致癌过程中给予高脂饮食的时间、脂肪与热量之间的相互作用，以及脂肪对癌症产生观察到的影响的潜在机制。脂肪中的必需脂肪酸、其不饱和程度以及不饱和键的位置，在决定膳食脂肪来源对致癌作用的影响方面都很重要。此外，膳食脂肪的改变对不同部位和形式的癌症有不同的影响。膳食脂肪已被明确证明在癌症促进过程中很重要，最近的研究表明，膳食脂肪也可能是癌症起始的一个因素。尽管高脂饮食所提供的热量也对癌症的发展有影响，但膳食脂肪似乎比其高热量密度的影响更大。膳食脂肪影响致癌作用的一种潜在机制是通过调节蛋白激酶C的激活。
