Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, The M. S. University of Baroda, Vadodara, Gujarat.
Cardiovasc Toxicol. 2012 Mar;12(1):73-82. doi: 10.1007/s12012-011-9140-0.
The present inventory evaluates anti-atherogenic potential of flavonoid-rich Eugenia jambolana seed extract (EJSE) against in vitro low-density lipoprotein (LDL) oxidation, foam cell formation, and atherogenic (ATH) diet-induced experimental atherosclerosis in rats. EJSE was able to prevent in vitro LDL oxidation and oxidized LDL-induced macrophage foam cell formation. Also, EJSE supplementation to ATH rats significantly minimized increment in serum markers of LDL oxidation. The ex vivo oxidation indices were also minimized in LDL of EJSE-treated animals. Microscopic evaluation of thoracic aorta of ATH + EJSE rats recorded minimal evidence of atheromatous plaque formation, accumulation of lipid laden macrophages, calcium deposition, and expression of cell adhesion molecules (vascular cell adhesion molecule-1 and P-selectin). This is the first scientific report that demonstrates anti-atherogenic potential of EJSE and warrants further evaluation at clinical level.
本研究旨在评估富含类黄酮的赤桉种子提取物（EJSE）的抗动脉粥样硬化潜力，评估其对体外低密度脂蛋白（LDL）氧化、泡沫细胞形成以及动脉粥样硬化饮食诱导的大鼠实验性动脉粥样硬化的作用。EJSE 能够预防体外 LDL 氧化和氧化 LDL 诱导的巨噬细胞泡沫细胞形成。此外，EJSE 补充剂对 ATH 大鼠的血清 LDL 氧化标志物的增加有显著的抑制作用。EJSE 处理动物的 LDL 中的体外氧化指标也有所降低。对 ATH+EJSE 大鼠胸主动脉的显微镜评估记录了最小的动脉粥样斑块形成、富含脂质的巨噬细胞积累、钙沉积以及细胞黏附分子（血管细胞黏附分子-1 和 P-选择素）表达的证据。这是第一项证明 EJSE 具有抗动脉粥样硬化潜力的科学报告，值得在临床水平上进一步评估。
