Chehab G, Fischer-Betz R, Schneider M
Klinik für Endokrinologie, Diabetologie und Rheumatologie, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
Z Rheumatol. 2011 Aug;70(6):480-5. doi: 10.1007/s00393-011-0758-x.
Systemic lupus erythematosus (SLE) is a chronic multisystem disease and despite the improvements in treatment, long-term care still represents a clinical challenge. Previous long-running studies have demonstrated a continuous improvement in mortality and this trend has persisted over the last two decades. However, there still remains a significantly increased mortality in comparison to the normal population. Besides deaths caused by disease activity, cardiovascular and infectious diseases also play a major role. While deaths caused by SLE activity or infections have declined over the years, there has been a notable increase in cardiovascular diseases. As the improvement of SLE activity and infections can be traced back to individually optimized treatment regimes and the more cautious use of steroids, the cardiovascular complications are due to accelerated atherosclerosis and the improved survival with ageing of the patients. This long-term aspect needs to be taken into account in the early stages of disease when treating disease activity and comorbidities.
系统性红斑狼疮（SLE）是一种慢性多系统疾病，尽管治疗有所改善，但长期护理仍是一项临床挑战。以往长期研究表明死亡率持续改善，这一趋势在过去二十年中一直存在。然而，与正常人群相比，死亡率仍显著增加。除了疾病活动导致的死亡外，心血管疾病和感染性疾病也起主要作用。虽然多年来由SLE活动或感染导致的死亡有所下降，但心血管疾病却显著增加。由于SLE活动和感染的改善可归因于个体化优化治疗方案以及更谨慎地使用类固醇，心血管并发症则是由于动脉粥样硬化加速以及患者随年龄增长生存率提高所致。在治疗疾病活动和合并症时，疾病早期就需要考虑这一长期因素。
