Richter J G, Klein-Weigel P, Brinks R, Schneider M, Sander O
Poliklinik für Rheumatologie, Heinrich-Heine-Universität Düsseldorf, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland,
Z Rheumatol. 2014 Sep;73(7):615-22. doi: 10.1007/s00393-014-1359-2.
Capillaroscopy is an established tool to assess morphological and functional findings of the microcirculation which have a confirmed association with disease activity and damage of inflammatory rheumatic diseases, especially systemic sclerosis. Hairpin-shaped capillaries with normal density predict a very low risk for collagenosis.
Own databases were evaluated with respect to the topic of the manuscript and the current literature was evaluated.
The healthy population does not only demonstrate hairpin shape as capillaroscopic normal findings and morphological and functional abnormalities can also be found which show various patterns depending on gender and age. These can be found in healthy persons and also patients with collagenosis. Ectasia and sludge phenomenon are more common in women and tortuous capillaries are more common in men. Capillary filling is often decreased in women and increased in male patients.
When assessing capillaroscopy findings, gender and the morphological or functional alterations which can be found in the normal healthy population should be taken into consideration. In further studies with capillaroscopy as the target parameter, the potential source of the disturbance should be known, especially in small populations, and if necessary balanced by weighted randomization.
毛细血管镜检查是一种既定的工具，用于评估微循环的形态学和功能学表现，这些表现已被证实与炎性风湿性疾病，尤其是系统性硬化症的疾病活动和损伤相关。密度正常的发夹状毛细血管提示胶原病风险极低。
对自有数据库进行了关于该手稿主题的评估，并对当前文献进行了评估。
健康人群不仅表现出发夹状作为毛细血管镜检查的正常表现，还能发现形态学和功能学异常，这些异常根据性别和年龄呈现出不同模式。这些异常在健康人和胶原病患者中均可发现。扩张和血流淤滞现象在女性中更常见，而迂曲的毛细血管在男性中更常见。女性的毛细血管充盈通常减少，男性患者则增加。
在评估毛细血管镜检查结果时，应考虑性别以及正常健康人群中可发现的形态学或功能学改变。在以毛细血管镜检查作为目标参数的进一步研究中，应了解干扰的潜在来源，尤其是在小样本人群中，如有必要，可通过加权随机化进行平衡。
