[波兰线粒体DNA数据库的饱和度]
[Saturation of the Polish mitochondrial DNA database].
作者信息
Daca Patrycja, Mielnik-Sikorska Marta, Bednarek Jarosław, Grzybowski Tomasz
机构信息
Z Zakładu Genetyki Molekularnej i Sadowej, Katedry Medycyny Sadowej Uniwersytetu Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy.
出版信息
Arch Med Sadowej Kryminol. 2010 Oct-Dec;60(4):263-9.
The main objective of the study was a statistical evaluation of Polish mitochondrial DNA database, consisting of 1253 maternally unrelated individuals from seven different regions of Poland. Four relevant parameters were examined: haplotype diversity, nucleotide diversity, number of polymorphic positions and number of haplotypes, including HVS I and HVS II mtDNA regions. The results show that while haplotype and nucleotide diversities have already reached saturation level, the number of haplotypes and polymorphic positions rises continuously inside the database. These results indicate a need for a substantial increase in the number of haplotypes in Polish mitochondrial DNA database.
该研究的主要目的是对波兰线粒体DNA数据库进行统计评估，该数据库由来自波兰七个不同地区的1253名母系无关个体组成。研究考察了四个相关参数：单倍型多样性、核苷酸多样性、多态性位点数量和单倍型数量，包括线粒体DNA高变区I（HVS I）和高变区II（HVS II）。结果表明，虽然单倍型和核苷酸多样性已达到饱和水平，但数据库内单倍型数量和多态性位点数量仍在持续增加。这些结果表明，波兰线粒体DNA数据库中的单倍型数量需要大幅增加。
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