Middle Tennessee State University, Department of Chemistry, Murfreesboro, Tennessee 37132, USA.
Org Lett. 2011 Sep 16;13(18):4879-81. doi: 10.1021/ol201828u. Epub 2011 Aug 24.
An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.
已经开发出一种有效的新型环丙基肽类似物的合成方法。该合成路线涉及使用乙基（二甲基硫代亚甲基）乙酸酯（EDSA）作为关键步骤的环丙烷化反应，并从保护的氨基酸 Weinreb 酰胺三步合成得到环丙基肽类似物核心。
