Department of Neurology, University of Chicago Medical Center, Chicago, IL 60637, USA.
Leuk Lymphoma. 2012 Mar;53(3):371-80. doi: 10.3109/10428194.2011.615426. Epub 2011 Sep 29.
Myasthenia gravis (MG) is an autoimmune disease mediated by antibodies to acetylcholine receptors (AChRs) or muscle specific tyrosine kinase (MuSK). While the frequent association of MG with thymoma in patients aged 40-60 years is well recognized, its occurrence in patients with lymphoma has not been well studied. We review the literature on the association of MG and lymphoid malignancies and report two new patients. MG can occur in a synchronous or non-synchronous fashion with lymphoma. The pathogenesis of MG in lymphoid malignancies is probably heterogeneous and likely relates to perturbations in the immune mechanisms that normally prevent the emergence of autoimmunity. These perturbations could be the result of the lymphoid malignancy per se, or its treatment.
重症肌无力（MG）是一种由乙酰胆碱受体（AChR）或肌肉特异性酪氨酸激酶（MuSK）抗体介导的自身免疫性疾病。虽然在年龄在 40-60 岁的患者中，MG 常与胸腺瘤相关已得到广泛认可，但在淋巴瘤患者中的发生情况尚未得到充分研究。我们复习了关于 MG 与淋巴恶性肿瘤相关的文献，并报告了两例新病例。MG 可与淋巴瘤同步或不同步发生。淋巴恶性肿瘤中 MG 的发病机制可能具有异质性，可能与正常情况下防止自身免疫出现的免疫机制紊乱有关。这些紊乱可能是恶性淋巴瘤本身或其治疗的结果。
