Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Climacteric. 2011 Oct;14(5):573-80. doi: 10.3109/13697137.2011.566652. Epub 2011 Aug 24.
Postmenopausal women seem to favor alternative therapies such as exercise and phytoestrogens as a substitute for potentially harmful hormone replacement therapy. Based on previous research, we hypothesized that phytoestrogens combined with exercise could have a synergic effect on women's health.
To verify whether phytoestrogens enhance the response to mixed training regarding menopausal symptoms and quality of life in postmenopausal women.
From a pool of women participating in a 6-month randomized, controlled exercise study, 21 received a placebo (mean age 58.3 ± 5.4 years, body mass index 29.8 ± 5.1 kg/m(2)) and 19 received phytoestrogen supplements (mean age 60.1 ± 3.4 years; body mass index 30.3 ± 4.6 kg/m(2)). Body weight, fat mass and lean body mass (dual-energy X-ray absorptiometry) were assessed. Quality of life was estimated by the Short Form-36 (SF-36) and Perceived Stress Scale-10 (PSS-10) questionnaires, and menopausal symptoms by the Kupperman index. All measurements were performed before and after the intervention.
Although the Kupperman index and PSS-10 remained unchanged in both groups, the SF-36 Physical Component Summary and almost all the SF-36 subscales (except for role-emotional and mental health) increased only in the exercise group taking phytoestrogens (0.001 < p < 0.04).
While phytoestrogens combined with mixed exercise were not sufficient to improve menopausal symptoms, it seemed to be a better strategy than exercise alone to improve the general quality of life in postmenopausal women.
绝经后女性似乎更倾向于选择替代疗法，如运动和植物雌激素，以替代可能有害的激素替代疗法。基于先前的研究，我们假设植物雌激素与运动相结合可能对女性健康具有协同作用。
验证植物雌激素是否能增强混合训练对绝经后妇女绝经症状和生活质量的反应。
从参加 6 个月随机对照运动研究的女性中，21 名接受安慰剂（平均年龄 58.3 ± 5.4 岁，体重指数 29.8 ± 5.1 kg/m²），19 名接受植物雌激素补充剂（平均年龄 60.1 ± 3.4 岁；体重指数 30.3 ± 4.6 kg/m²）。评估体重、体脂肪量和去脂体重（双能 X 射线吸收法）。采用简明健康调查问卷（SF-36）和压力知觉量表 10 项（PSS-10）评估生活质量，采用库珀曼指数评估绝经症状。所有测量均在干预前后进行。
尽管两组的库珀曼指数和 PSS-10 均保持不变，但仅在服用植物雌激素的运动组中，SF-36 生理机能成分总分和几乎所有 SF-36 子量表（除角色情感和心理健康外）均有所增加（0.001 < p < 0.04）。
虽然植物雌激素联合混合运动不足以改善绝经症状，但它似乎是改善绝经后妇女总体生活质量的比单独运动更好的策略。
