Brook I, Elliott T B, Ledney G D
Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland.
Radiat Res. 1990 May;122(2):215-7.
Exposure to whole-body irradiation is associated with fatal gram-negative sepsis. The effect of oral therapy with three quinolones, pefloxacin, ciprofloxacin, and ofloxacin, for orally acquired Klebsiella pneumoniae infection was tested in B6D2F1 mice exposed to 8.0 Gy whole-body irradiation from bilaterally positioned 60Co sources. A dose of 10(8) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Quinolones reduced colonization of the ileum with K. pneumoniae: 16 of 28 (57%) untreated mice harbored the organisms, compared to only 12 of 90 (13%) mice treated with quinolones (P less than 0.005). K. pneumoniae was isolated from the livers of 6 of 28 untreated mice, compared to only 1 of 90 treated mice (P less than 0.001). Only 5 of 20 (25%) untreated mice survived for at least 30 days compared with 17 of 20 (85%) mice treated with ofloxacin, 15 of 20 (75%) mice treated with pefloxacin, and 14 of 20 (70%) treated with ciprofloxacin (P less than 0.05). These data illustrate the efficacy of quinolones for oral therapy of orally acquired K. pneumoniae infection in irradiated hosts.
全身照射与致命的革兰氏阴性败血症有关。在从双侧放置的60Co源接受8.0 Gy全身照射的B6D2F1小鼠中，测试了三种喹诺酮类药物（培氟沙星、环丙沙星和氧氟沙星）口服治疗经口感染肺炎克雷伯菌的效果。照射后2天口服给予10(8)个菌量，1天后开始治疗。喹诺酮类药物减少了肺炎克雷伯菌在回肠的定植：28只未治疗小鼠中有16只（57%）携带该菌，而喹诺酮类药物治疗的90只小鼠中只有12只（13%）携带（P<0.005）。28只未治疗小鼠中有6只肝脏分离出肺炎克雷伯菌，而治疗小鼠中只有90只中的1只（P<0.001）。20只未治疗小鼠中只有5只（25%）存活至少30天，相比之下，氧氟沙星治疗的20只小鼠中有17只（85%）、培氟沙星治疗的20只小鼠中有15只（75%）、环丙沙星治疗的20只小鼠中有14只（70%）存活（P<0.05）。这些数据说明了喹诺酮类药物对经口感染肺炎克雷伯菌的受照射宿主进行口服治疗的有效性。
