Genome Research Laboratory, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar Sec-3, M B Road, New Delhi-110017, India.
Microvasc Res. 2011 Nov;82(3):263-8. doi: 10.1016/j.mvr.2011.08.002. Epub 2011 Aug 12.
The aim of the present study was to investigate the effects of boswellic acid (BA) on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and BA (12.5 or 25mg/kg/day) was given through installed cannulas for nine days. The implants collected at day 9 post-implantation were processed for the assessment of hemoglobin (Hb). Relevant levels of inflammatory, angiogenic and fibrogenic cytokines were also determined. BA treatment resulted in significant decrease in sponge vascularization (Hb content) and in vascular endothelial growth factor (VEGF) and transforming growth factor (TGF-β1) at both doses. Further, BA decreased expression of VEGF and CD31 and reduced % microvessel density (MVD) in sponge implants. A regulatory function of BA on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving an insight into the potential therapeutic use underlying the actions of BA.
本研究旨在探讨乳香酸（BA）对小鼠套管海绵植入血管生成模型中炎症性血管生成关键成分的影响。聚酯-聚氨基甲酸酯海绵作为纤维血管组织生长的框架，植入瑞士白化小鼠体内，并通过植入的套管给予 BA（每天 12.5 或 25mg/kg），共 9 天。植入后第 9 天收集的植入物用于评估血红蛋白（Hb）。还测定了相关水平的炎症、血管生成和纤维生成细胞因子。BA 治疗在两种剂量下均导致海绵血管化（Hb 含量）和血管内皮生长因子（VEGF）和转化生长因子（TGF-β1）显著降低。此外，BA 降低了 VEGF 和 CD31 的表达，并减少了海绵植入物中微血管密度（MVD）的%。BA 对炎症性血管生成主要成分的多个参数具有调节作用，这为 BA 作用的潜在治疗用途提供了深入了解。
