Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
Res Vet Sci. 2012 Aug;93(1):427-9. doi: 10.1016/j.rvsc.2011.07.025. Epub 2011 Aug 23.
The purpose of this study was to evaluate the feasibility of proton magnetic resonance spectroscopy (1H MRS) to study the concentration of metabolites in the brain of dogs at 3.0 and 7.0 T. Four healthy male beagles were scanned using 3.0 T and 7.0 T human magnetic resonance imaging (MRI) units. The results obtained showed that all dogs had excellent quality spectra for a small (1 cm3) and large (8 cm3) voxel at 3.0 T, whereas only 2 dogs had high quality spectra at 7.0 T due to insufficient water suppression. 1H MRS at 3.0 T appears to be a reliable method to study metabolite concentrations in the canine brain. The development of more advanced water suppression techniques is necessary to improve the results at 7.0 T.
本研究旨在评估质子磁共振波谱（1H MRS）在 3.0 和 7.0 T 下研究犬脑代谢物浓度的可行性。使用 3.0 T 和 7.0 T 人体磁共振成像（MRI）仪对 4 只健康雄性比格犬进行了扫描。结果表明，所有犬在 3.0 T 时均具有小（1 cm3）大和（8 cm3）大体积的高质量光谱，而由于水抑制不足，只有 2 只犬在 7.0 T 时具有高质量光谱。3.0 T 的 1H MRS 似乎是一种可靠的方法，可以研究犬脑代谢物浓度。需要开发更先进的水抑制技术来提高 7.0 T 的结果。
