Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Diabetes Res Clin Pract. 2011 Nov;94(2):291-8. doi: 10.1016/j.diabres.2011.07.032. Epub 2011 Aug 23.
To describe the relationship of retinal arteriolar and venular caliber with diabetes, retinopathy and hyperglycemia, in an Asian Indian population.
This was a population-based cross-sectional study of 3400 (75.6% response rate) Singapore ethnic Indians aged 40-80 years. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were obtained using a validated computer-assisted program. Diabetes mellitus was identified using standardized criteria. Diabetic retinopathy was graded based on the modified Airlie House Classification System.
There were 980 (32.2%) participants with diabetes. Of these, 327 (33.4%) had diabetic retinopathy. After multivariate adjustment, diabetic persons had a wider CRAE (145.23μm vs 142.38μm, P<0.001). This relationship was stronger in persons without hyperlipidemia (P-interaction<0.1). Among diabetic participants, wider CRVE was related to increasing severity of retinopathy (P for trend<0.05) and this association may be altered by hypertensive status. Retinal arteriolar caliber widened with increasing glucose (P<0.001) and HbA1C (P<0.001) levels.
In Indian adults, wider retinal arteriolar caliber is associated with diabetes and hyperglycemia, while wider retinal venular caliber is associated with diabetic retinopathy. This is consistent with white populations and confirms the differential systemic association of retinal vascular caliber in Asian Indians.
描述亚洲印度人群中视网膜小动脉和小静脉直径与糖尿病、视网膜病变和高血糖之间的关系。
这是一项基于人群的横断面研究，共纳入 3400 名（75.6%的应答率）年龄在 40-80 岁的新加坡印度裔人群。使用经过验证的计算机辅助程序获得视网膜中央小动脉等效直径（CRAE）和视网膜中央小静脉等效直径（CRVE）。使用标准化标准来确定糖尿病。根据改良的 Airlie House 分类系统对糖尿病视网膜病变进行分级。
共有 980 名（32.2%）参与者患有糖尿病。其中，327 名（33.4%）患有糖尿病视网膜病变。经过多变量调整后，糖尿病患者的 CRAE 更宽（145.23μm 比 142.38μm，P<0.001）。在没有高脂血症的人群中，这种关系更强（P 交互<0.1）。在糖尿病患者中，CRVE 越宽与视网膜病变严重程度呈正相关（趋势 P 值<0.05），这种关联可能受高血压状态的影响。视网膜小动脉直径随血糖（P<0.001）和糖化血红蛋白（HbA1C）（P<0.001）水平升高而变宽。
在印度成年人中，视网膜小动脉直径变宽与糖尿病和高血糖有关，而视网膜小静脉直径变宽与糖尿病视网膜病变有关。这与白人人群一致，并证实了亚洲印度人群视网膜血管直径的系统关联存在差异。
