Centre for Eye Research Australia, University of Melbourne, Australia.
Eye (Lond). 2009 Aug;23(8):1719-24. doi: 10.1038/eye.2008.362. Epub 2008 Dec 12.
To describe the relationship of retinal vascular calibre with diabetes and diabetic retinopathy in an Asian population.
A total of 3280 (78.7% response) subjects, aged 40-80 years, of Malay ethnicity residing in Singapore participated in this population-based, cross-sectional study. Retinal vascular calibre was measured and summarized using a validated computer programme from digital retinal photographs. Diabetic retinopathy signs were graded from photographs using the modified Airlie House classification.
Of the 3004 subjects with data for this analysis, 682 (22.7%) had diabetes, of whom 194 (28.4%) had retinopathy. After multivariable adjustment, retinal arteriolar calibre was significantly wider in persons with diabetes (141 vs139 microm, P<0.001); venular calibre was not associated with diabetes (P=0.93). Among participants with diabetes, venular calibre increased from 218.7 microm in those without retinopathy to 231.1 microm in those with moderate and 231.4 microm in those with severe retinopathy (Pfor trend=<0.001); arteriolar calibre was not associated with diabetic retinopathy.
This study shows wider retinal arterioles in diabetes and wider venules in those with diabetic retinopathy in an Asian population. These findings confirm earlier data on white population, supporting the concept that a quantitative assessment of retinal vasculature may provide further insights into early diabetic microvascular damage.
描述亚洲人群中视网膜血管口径与糖尿病和糖尿病性视网膜病变的关系。
共有 3280 名（78.7%的应答率）年龄在 40-80 岁的马来族裔居民参与了这项基于人群的横断面研究。使用经过验证的计算机程序从数字视网膜照片中测量和总结视网膜血管口径。使用改良的 Airlie House 分类法从照片中分级糖尿病性视网膜病变的征象。
在这项分析中有数据的 3004 名受试者中，682 名（22.7%）患有糖尿病，其中 194 名（28.4%）患有视网膜病变。经过多变量调整后，糖尿病患者的视网膜小动脉口径明显变宽（141 对 139 微米，P<0.001）；静脉口径与糖尿病无关（P=0.93）。在患有糖尿病的参与者中，静脉口径从无视网膜病变者的 218.7 微米增加到中度视网膜病变者的 231.1 微米和严重视网膜病变者的 231.4 微米（趋势 P<0.001）；小动脉口径与糖尿病性视网膜病变无关。
本研究表明，亚洲人群中糖尿病患者的视网膜小动脉较宽，糖尿病性视网膜病变患者的静脉较宽。这些发现证实了白人人群的早期数据，支持了定量评估视网膜血管可能提供对早期糖尿病微血管损伤的进一步见解的概念。
