[大鼠适应寒冷过程中脑和肾钠钾ATP酶的激活]
[Brain and kidney, Na, K-ATPase activation in the rat in adaptation to cold].
作者信息
Larionov N P, Medvedev L N, Khramenko S A
出版信息
Biull Eksp Biol Med. 1979 Mar;87(3):221-2.
PMID:218652
Abstract
The activity of Na,K-ATPase of the rat brain and kidney is 1.5--2-fold as increased during intermittent and prolonged (16 weeks) adaptation to cold, without changes in the enzyme affinity to ATP. It is suggested that adaptive increase in the power of the Na pump, triidothyronine-dependent in the kidneys and triiodothyronine-independent in the brain, ensures elevation in thermal production to body cooling.
摘要
在对寒冷进行间歇性和长期（16周）适应的过程中，大鼠脑和肾的钠钾ATP酶活性增加了1.5至2倍，而该酶对ATP的亲和力并无变化。研究表明，钠泵功能的适应性增强，在肾脏中依赖于三碘甲状腺原氨酸，在脑中则不依赖于三碘甲状腺原氨酸，可确保产热增加以应对身体散热。
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