Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA.
AIDS. 2011 Nov 13;25(17):2157-65. doi: 10.1097/QAD.0b013e32834bfde9.
To understand patterns of HIV transmission among young black MSM and others in Mississippi.
Phylogenetic analysis of HIV-1 polymerase (pol) sequences from 799 antiretroviral-naive persons newly diagnosed with HIV infection in Mississippi during 2005-2008, 130 (16%) of whom were black MSM aged 16-25 years.
We identified phylogenetic clusters and used surveillance data to evaluate demographic attributes and risk factors of all persons in clusters that included black MSM aged 16-25 years.
We identified 82 phylogenetic clusters, 21 (26%) of which included HIV strains from at least one young black MSM. Of the 69 persons in these clusters, 59 were black MSM and seven were black men with unknown transmission category; the remaining three were MSM of white or Hispanic race/ethnicity. Of these 21 clusters, 10 included residents of one geographic region of Mississippi, whereas 11 included residents of multiple regions or outside of the state.
Phylogenetic clusters involving HIV-infected young black MSM were homogeneous with respect to demographic and risk characteristics, suggesting insularity of this population with respect to HIV transmission, but were geographically heterogeneous. Reducing HIV transmission among young black MSM in Mississippi may require prevention strategies that are tailored to young black MSM and those in their sexual networks, and prevention interventions should be delivered in a manner to reach young black MSM throughout the state. Phylogenetic analysis can be a tool for local jurisdictions to understand the transmission dynamics in their areas.
了解密西西比州年轻的黑人男男性行为者和其他人群中 HIV 的传播模式。
对 2005-2008 年期间在密西西比州新诊断出感染艾滋病毒的 799 名未接受抗逆转录病毒治疗的人群的 HIV-1 聚合酶（pol）序列进行系统进化分析，其中 130 名（16%）为年龄在 16-25 岁的黑人男男性行为者。
我们确定了系统进化簇，并利用监测数据评估了所有包含年龄在 16-25 岁的黑人男男性行为者的簇中的人群的人口统计学特征和危险因素。
我们确定了 82 个系统进化簇，其中 21 个（26%）簇包含至少一个年轻的黑人男男性行为者的 HIV 株。在这些簇中的 69 人中，59 人为黑人男男性行为者，7 人为黑人男性，传播途径未知；其余 3 人为白人或西班牙裔的男男性行为者。在这 21 个簇中，有 10 个簇包含密西西比州一个地理区域的居民，而 11 个簇包含多个地区或州外的居民。
涉及感染 HIV 的年轻黑人男男性行为者的系统进化簇在人口统计学和风险特征方面具有同质性，表明该人群在 HIV 传播方面具有孤立性，但在地理上存在异质性。要减少密西西比州年轻黑人男男性行为者中的 HIV 传播，可能需要针对年轻的黑人男男性行为者及其性网络中的人群制定专门的预防策略，并且预防干预措施应该以能够接触到全州范围内的年轻黑人男男性行为者的方式提供。系统进化分析可以成为地方司法管辖区了解其地区传播动态的一种工具。
