（+）-麦角酸的全合成。
Total synthesis of (+)-lysergic acid.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
出版信息
Org Lett. 2011 Sep 16;13(18):4810-3. doi: 10.1021/ol2018467. Epub 2011 Aug 25.
PMID:21866948
Abstract
A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the B ring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.
摘要
采用三种金属催化方法构建三个关键环，实现了（+）-麦角酸（1）的立体控制全合成。该合成的亮点包括 Pd 催化吲哚合成形成 B 环、RCM 反应形成 D 环和分子内 Heck 反应形成 C 环。
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