Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.
J Antibiot (Tokyo). 2018 Feb;71(2):240-247. doi: 10.1038/ja.2017.80. Epub 2017 Jul 19.
A total synthesis of (+)-lysergic acid, which features the C-C bond formation between C10 and C11 via cleavage of an aziridine ring, was accomplished.
(+)-麦角酸的全合成,通过环氧化合物开环反应在 C10 和 C11 之间形成 C-C 键,已完成。