Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research), Unit of Medical Chemistry and GIGA-Signal Transduction, University of Liege, CHU, Sart-Tilman, 4000 Liège, Belgium.
Breast Cancer Res. 2011 Jul 26;13(4):214. doi: 10.1186/bcr2886.
Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated.
自我更新的乳腺癌干细胞是维持肿瘤存在、治疗抵抗和复发的关键因素。目前开始阐明维持它们所需的分子途径。其中包括转录因子 NF-κB，已知其在细胞存活、炎症和免疫中发挥关键作用。最近的研究表明，乳腺上皮 NF-κB 在 Her2 依赖性肿瘤发生模型中调节乳腺癌干细胞的自我更新。我们将在这里描述参与该过程的 NF-κB 激活途径以及该转录因子在其中实际激活的祖细胞。
