Stowers Institute for Medical Research, Kansas City, Missouri.
The Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas.
Cancer Res. 2023 Jul 5;83(13):2096-2104. doi: 10.1158/0008-5472.CAN-23-0230.
Use of immunotherapy in recent years has revolutionized cancer treatment for certain types of cancers. However, the broad utility of immunotherapy is limited because there are still many types of cancer that do not respond effectively. Failure of a cancer to respond is due, at least in part, to its phenotypic plasticity, a feature that is established by cancer stem cells (CSC) and their associated microenvironments. This article discusses the current understanding of CSC-mediated immune evasion and provides a prospective view on how researchers can better understand and overcome the intrinsic immune privilege of CSCs and the extrinsic immune-suppressive microenvironment shaped by them.
近年来，免疫疗法的应用彻底改变了某些类型癌症的治疗方式。然而，免疫疗法的广泛应用仍然受到限制，因为仍有许多类型的癌症对其反应不佳。癌症对免疫疗法的反应失败，至少部分是由于其表型可塑性，这种特征是由癌症干细胞（CSC）及其相关微环境建立的。本文讨论了目前对 CSC 介导的免疫逃逸的理解，并对研究人员如何更好地理解和克服 CSC 的内在免疫特权以及由其塑造的外在免疫抑制微环境提供了前瞻性的观点。
