少弱畸形精子症伴或不伴精索静脉曲张患者精子 caspase-9。
Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele.
机构信息
Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
Fertil Steril. 2011 Nov;96(5):1097-9. doi: 10.1016/j.fertnstert.2011.08.004. Epub 2011 Aug 24.
OBJECTIVE
To assess sperm caspase-9 activity in infertile oligoasthenoteratozoospermic (OAT) men with and without varicocele.
DESIGN
Prospective.
SETTING
Academic setting.
PATIENT(S): Eighty men: healthy fertile control subjects (n = 20), OAT (n = 25), and OAT associated with left-side varicocele (n = 35).
INTERVENTION(S): History taking, clinical examination, semen analysis,assessment of seminal caspase-9.
MAIN OUTCOME MEASURE(S): Semen analysis, sperm caspase-9.
RESULT(S): Sperm caspase-9 was significantly increased in infertile OAT men associated with varicocele compared with OAT men without varicocele and healthy fertile control subjects. Sperm casapse-9 activity demonstrated significant negative correlation with sperm count, sperm motility, sperm velocity, sperm linear velocity, sperm linearity index, and sperm normal morphology.
CONCLUSION(S): Sperm caspase-9 is exaggerated in infertile OAT cases with varicocele compared with infertile OAT cases without varicocele or healthy fertile men. Sperm caspase-9 demonstrated significant negative correlation with semen variables.
目的
评估伴有和不伴有精索静脉曲张的少弱畸精子症（OAT）男性的精子半胱天冬酶-9 活性。
设计
前瞻性研究。
地点
学术环境。
患者
80 名男性：健康的有生育能力的对照组（n=20）、OAT（n=25）和 OAT 伴左侧精索静脉曲张（n=35）。
干预措施
病史采集、临床检查、精液分析、检测精子半胱天冬酶-9。
主要观察指标
精液分析，精子半胱天冬酶-9。
结果
与不伴有精索静脉曲张的 OAT 男性和健康有生育能力的对照组相比，伴有精索静脉曲张的 OAT 男性的精子半胱天冬酶-9 显著增加。精子半胱天冬酶-9 活性与精子计数、精子活力、精子速度、精子线性速度、精子直线性指数和精子正常形态显著负相关。
结论
与不伴有精索静脉曲张的 OAT 男性或健康有生育能力的男性相比，伴有精索静脉曲张的 OAT 男性的精子半胱天冬酶-9 明显增加。精子半胱天冬酶-9 与精液变量呈显著负相关。
Zotero 插件