Butler Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI, USA.
Neurology. 2013 Jun 11;80(24):2269-70. doi: 10.1212/WNL.0b013e318296e9d5. Epub 2013 May 15.
Impulse control disorders (ICD) and the dopamine dysregulation syndrome (DDS) are dopaminergic complications of Parkinson disease (PD) treatment. A large number of ICDs have been associated with dopamine agonists (DAA), such as gambling, hypersexuality, and consumerism, but none, to our knowledge, involved drugs of abuse. DDS is a condition in which patients with PD abuse l-dopa, taking it excessively despite the dyskinesias or psychotic symptoms that result. DDS produces l-dopa craving, whereas ICDs produce compulsions, and the 2 may coexist. DDS has rarely been associated with dopamine agonists other than apomorphine.
冲动控制障碍（ICD）和多巴胺失调综合征（DDS）是帕金森病（PD）治疗的多巴胺能并发症。大量的 ICD 与多巴胺激动剂（DAA）有关，如赌博、性欲亢进和消费主义，但据我们所知，没有一种与滥用药物有关。DDS 是一种 PD 患者滥用左旋多巴的疾病，尽管会出现运动障碍或精神病症状，但仍过度服用。DDS 会产生左旋多巴的渴望，而 ICD 会产生强迫，两者可能并存。除了阿朴吗啡外，DDS 很少与其他多巴胺激动剂有关。
