Department of Twin Research, King's College London, St. Thomas' Hospital, London, UK.
Semin Arthritis Rheum. 2012 Feb;41(4):568-75. doi: 10.1016/j.semarthrit.2011.07.002. Epub 2011 Aug 24.
To determine cross-sectionally the influence of risk factors on chronic pain following total joint replacement (TJR) of the knee (TKR) or the hip (THR).
Eight hundred sixty post-TKR and 928 post-THR patients were studied. Western Ontario and McMaster Osteoarthritis Index pain scores taken on average 3.2 years postsurgery were correlated to preoperative radiographic severity measured by Kellgren-Lawrence grade (K/L) grade for the knee, Croft grade, and minimum joint space width (minJSW) for the hip and presence of comorbidities.
Known risk factors were able to explain less than 20% of the variance in pain scores post-TJR. The presence of chronic widespread pain determined a higher risk of high pain in both TKR cases (odds ratio (OR) = 3.15 95%CI 1.86-5.30) and THR cases (OR = 5.02 95%CI 2.76-9.14). Other risk factors common to both TKR and THR pain postsurgery were the presence of depression, higher body mass index, younger age, and female gender. Interestingly, low radiographic grade at the index joint presurgery (defined as tibiofemoral K/L <3 for the knee and minJSW >2 mm for the hip) resulted in a significantly increased risk of high pain post-TJR (OR = 1.56; 95%CI 1.04-2.36).
The risk factors contributing to chronic pain post-TJR remain mostly unknown. Individuals with lower preoperative radiographic OA severity undergoing TJR are more likely to experience high pain post-TJR.
确定膝关节(TKR)或髋关节(THR)全关节置换(TJR)后慢性疼痛的危险因素的横断面影响。
研究了 86 例 TKR 后和 928 例 THR 后患者。平均术后 3.2 年测量的 Western Ontario 和 McMaster 骨关节炎指数疼痛评分与术前通过 Kellgren-Lawrence 分级(K/L)分级、Croft 分级和最小关节间隙宽度(minJSW)对膝关节、并存疾病对髋关节进行放射学严重程度相关。
已知的危险因素只能解释 TJR 后疼痛评分变异的不到 20%。慢性广泛性疼痛的存在使 TKR 病例(优势比(OR)=3.15,95%CI 1.86-5.30)和 THR 病例(OR = 5.02,95%CI 2.76-9.14)中出现高疼痛的风险更高。手术治疗后 TKR 和 THR 疼痛的其他共同危险因素包括存在抑郁、较高的体重指数、较年轻的年龄和女性性别。有趣的是,术前索引关节的放射学分级较低(定义为膝关节的胫股关节 K/L <3 和髋关节的 minJSW >2mm)导致 TJR 后高疼痛的风险显著增加(OR = 1.56;95%CI 1.04-2.36)。
导致 TJR 后慢性疼痛的危险因素仍大多未知。接受 TJR 的术前放射学 OA 严重程度较低的个体更有可能在 TJR 后经历高疼痛。