Haddad Bassem, Alhosanie Tasneem N, Yousef Noor, Kanaan Ali, Mazahreh Leen A, Mohammad Khuzama, Al-Zurgan Aya, Al-Zghoul Leen, Mesmar Tala M, Alabhoul Fahad, Abuawad Abdel Rahman, Abuhajleh Feras, Hamdan Mohammad
Division of Orthopedics, School of Medicine, Department of Special Surgery The University of Jordan Amman Jordan.
Software Engineering Department King Hussein School of Computing Sciences Princess Sumaya University for Technology Amman Jordan.
J Exp Orthop. 2025 Jul 18;12(3):e70314. doi: 10.1002/jeo2.70314. eCollection 2025 Jul.
Knee osteoarthritis (OA) is a leading cause of disability and chronic pain; total knee arthroplasty (TKA) is the effective treatment in the end stages of knee OA after failure of conservative management. This study has focused on the effects of primary TKA on knee function, levels of depression, and anxiety.
The study population is a cohort of 100 patients who underwent primary TKA in a tertiary center in Jordan. Oxford Knee Score (OKS), Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 score assessments were performed preoperatively and three months postoperatively.
The results showed a dramatic improvement in knee function, with the mean OKS increasing from 17.9 preoperatively to 38.4 postoperatively ( < 0.001). Moreover, the percentage of patients who reported no or mild depression increased from 62% to 91%, and those who reported minimal or mild anxiety also increased from 76% to 95%. A multivariate linear regression showed that age, osteoporosis, and smoking were independently associated with the anxiety and depression score changes. These represent not only pain improvement but also a dual benefit in the field of mental health following TKA.
Primary TKA showed significant improvement in patients' depression and anxiety, along with the improvement of their knee functional scores. Discussing psychological factors with patients preoperatively might be important along with the functional outcome in making the surgical decision.
Level II, prospective cohort study.
膝关节骨关节炎（OA）是导致残疾和慢性疼痛的主要原因；全膝关节置换术（TKA）是保守治疗失败后膝关节OA终末期的有效治疗方法。本研究聚焦于初次TKA对膝关节功能、抑郁水平和焦虑水平的影响。
研究人群为在约旦一家三级中心接受初次TKA的100例患者队列。术前及术后三个月进行牛津膝关节评分（OKS）、患者健康问卷-9和广泛性焦虑障碍-7评分评估。
结果显示膝关节功能有显著改善,平均OKS从术前的17.9提高到术后的38.4（<0.001）。此外，报告无抑郁或轻度抑郁的患者比例从62%增至91%，报告极少或轻度焦虑的患者比例也从76%增至95%。多变量线性回归显示年龄、骨质疏松和吸烟与焦虑和抑郁评分变化独立相关。这些不仅代表疼痛改善，还表明TKA术后在心理健康方面有双重益处。
初次TKA使患者的抑郁和焦虑显著改善，同时膝关节功能评分也得到提高。术前与患者讨论心理因素以及功能结果对于做出手术决策可能很重要。
二级，前瞻性队列研究。
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