Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel.
Learn Mem. 2011 Aug 25;18(9):594-7. doi: 10.1101/lm.2231911. Print 2011 Sep.
Learning of a particularly difficult olfactory-discrimination (OD) task results in acquisition of rule learning. This enhancement in learning capability is accompanied by the long-term enhancement of synaptic connectivity between piriform cortex pyramidal neurons. In this study we examined whether olfactory rule learning would modify the predisposition to induce long-term potentiation (LTP) in the pathway projecting from the piriform cortex to the olfactory bulb. We report that OD learning was associated with enhancement in the predisposition to induce LTP. This learning-related effect may be affected by process generation of new granule cells located in the olfactory bulb.
学习一项特别困难的嗅觉辨别（OD）任务会导致规则学习的获得。这种学习能力的增强伴随着梨状皮层锥体神经元之间突触连接的长期增强。在这项研究中，我们研究了嗅觉规则学习是否会改变从梨状皮层投射到嗅球的通路中诱导长时程增强（LTP）的倾向。我们报告说，OD 学习与诱导 LTP 的倾向增强有关。这种与学习相关的效应可能受到位于嗅球中的新颗粒细胞生成过程的影响。
