Abelovska Lenka
Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH1, 842 15 Bratislava, Slovak Republic.
Gen Physiol Biophys. 2011;30 Spec No:S13-24. doi: 10.4149/gpb_2011_SI1_13.
Yeast mitochondria constitute a complex dynamic tubular reticulum almost continually undergoing fission, fusion, and movements along cytoskeletal filaments. Besides machineries directly implicated in these processes, a large group of diverse proteins, whose exact contribution is still a matter of debate, also influence mitochondrial shape. This review focuses on those factors that seem to affect morphogenesis only indirectly, through their involvement in mitochondrial protein import, lipid supply, inheritance, or ion homeostasis. Many of them stand on the intersections of pathways contributing to mitochondrial biogenesis. Their absence has multiple phenotypic consequences, one of the most distinctive being the loss of the typical tubular shape of these organelles.
酵母线粒体构成一个复杂的动态管状网络，几乎持续经历裂变、融合以及沿细胞骨架丝的移动。除了直接参与这些过程的机制外，一大类功能多样的蛋白质（其确切作用仍存在争议）也会影响线粒体的形态。本综述聚焦于那些似乎仅通过参与线粒体蛋白质导入、脂质供应、遗传或离子稳态而间接影响形态发生的因素。它们中的许多处于有助于线粒体生物发生的途径的交叉点上。它们的缺失会产生多种表型后果，其中最显著的之一是这些细胞器典型管状形态的丧失。
