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Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia.

作者信息

Szymon Skoczen, Bik-Multanowski Miroslaw, Balwierz Walentyna, Pietrzyk Jacek J, Surmiak Marcin, Strojny Wojciech, Galicka-Latala Danuta, Gozdzik Jolanta

机构信息

Jagiellonian University Medical College, 30-663 Krakow, Poland.

出版信息

J Genet. 2011 Aug;90(2):365-8. doi: 10.1007/s12041-011-0089-3.

DOI:10.1007/s12041-011-0089-3
PMID:21869491
Abstract
摘要

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Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia.FTO基因rs9939609T等位基因的纯合性可能对儿童急性淋巴细胞白血病幸存者超重具有保护作用。
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Rofo. 2019 Aug;191(8):752-753. doi: 10.1055/a-0835-6943. Epub 2019 Mar 21.
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Adv Sci (Weinh). 2023 Jan;10(2):e2201724. doi: 10.1002/advs.202201724. Epub 2022 Dec 7.
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Novel Associations Between Gene Polymorphisms and Pediatric Acute Lymphoblastic Leukemia: A Five-Center Case-Control Study.基因多态性与儿童急性淋巴细胞白血病之间的新型关联：一项五中心病例对照研究。
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本文引用的文献

1
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.全基因组关联研究中鉴定的肥胖相关基因座在儿童 BMI 测定中的作用。
Obesity (Silver Spring). 2009 Dec;17(12):2254-7. doi: 10.1038/oby.2009.159. Epub 2009 May 28.
2
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.黑皮质素4受体（MC4R）和脂肪量和肥胖相关基因（FTO）常见基因变异对欧洲普通人群肥胖的联合影响。
J Mol Med (Berl). 2009 May;87(5):537-46. doi: 10.1007/s00109-009-0451-6. Epub 2009 Mar 3.
3
Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.
儿童急性淋巴细胞白血病幸存者中特定基因多态性相关的晚期效应。
Ital J Pediatr. 2018 Aug 15;44(1):92. doi: 10.1186/s13052-018-0526-5.
4
Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism?儿童癌症治疗后的心血管危险因素与FTO基因多态性无关吗？
Int J Endocrinol. 2018 Feb 20;2018:7495234. doi: 10.1155/2018/7495234. eCollection 2018.
5
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors.儿童急性淋巴细胞白血病幸存者长期心脏代谢并发症的基因组决定因素。
BMC Cancer. 2017 Nov 10;17(1):751. doi: 10.1186/s12885-017-3722-6.
6
Evaluation of Metabolic Syndrome and Related Factors in Children Affected by Acute Lymphoblastic Leukemia.急性淋巴细胞白血病患儿的代谢综合征及相关因素评估
Indian J Med Paediatr Oncol. 2017 Apr-Jun;38(2):97-102. doi: 10.4103/ijmpo.ijmpo_69_16.
7
Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia.儿童白血病成年幸存者中的肥胖与代谢综合征
Curr Treat Options Oncol. 2016 Apr;17(4):17. doi: 10.1007/s11864-016-0393-5.
INSIG2 和 FTO 对一年生活方式干预减重的加重作用。
Arch Dis Child. 2009 Dec;94(12):965-7. doi: 10.1136/adc.2008.147652. Epub 2009 Feb 17.
4
An obesity-associated FTO gene variant and increased energy intake in children.一种与肥胖相关的FTO基因变体与儿童能量摄入增加
N Engl J Med. 2008 Dec 11;359(24):2558-66. doi: 10.1056/NEJMoa0803839.
5
Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.在魁北克家族研究中，FTO基因变异影响肥胖、胰岛素敏感性、瘦素水平和静息代谢率。
Diabetes. 2008 Apr;57(4):1147-50. doi: 10.2337/db07-1267. Epub 2008 Mar 3.
6
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.早发性极度肥胖的全基因组关联（GWA）研究支持脂肪量和肥胖相关基因（FTO）变异的作用。
PLoS One. 2007 Dec 26;2(12):e1361. doi: 10.1371/journal.pone.0001361.
7
Assessment of child and adolescent overweight and obesity.儿童及青少年超重与肥胖的评估
Pediatrics. 2007 Dec;120 Suppl 4:S193-228. doi: 10.1542/peds.2007-2329D.
8
Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.专家委员会关于儿童及青少年超重与肥胖的预防、评估和治疗的建议：总结报告
Pediatrics. 2007 Dec;120 Suppl 4:S164-92. doi: 10.1542/peds.2007-2329C.
9
Obesity and hypertension among children after treatment for acute lymphoblastic leukemia.急性淋巴细胞白血病治疗后儿童的肥胖与高血压
Cancer. 2007 Nov 15;110(10):2313-20. doi: 10.1002/cncr.23050.
10
Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病幸存者的腹部肥胖、肝脏脂肪和肌肉组成
J Clin Endocrinol Metab. 2007 Oct;92(10):3816-21. doi: 10.1210/jc.2006-2178. Epub 2007 Jul 24.