Department of Kinanthropology, Université du Québec à Montréal, Montreal, Quebec, Canada.
Obesity (Silver Spring). 2012 Apr;20(4):886-90. doi: 10.1038/oby.2011.273. Epub 2011 Aug 25.
The purpose of this study was to investigate the relationship between visceral adipose tissue (VAT), estimated with the Bertin index obtained from dual-energy X-ray absorptiometry (DXA), with cardiometabolic risk factors before and after a weight loss program and compare it with VAT measured with computed tomography (CT) scan. The study population for this analysis included 92 nondiabetic overweight and obese sedentary postmenopausal women (age: 58.1 ± 4.7 years, BMI: 31.8 ± 4.2 kg/m(2)) participating in a weight loss intervention that consisted of a caloric restricted diet with and without resistance training (RT). We measured (i) VAT using CT scan, (ii) body composition (using DXA) from which the Bertin index was calculated, (iii) cardiometabolic risk factors such as insulin sensitivity (using the hyperinsulinenic-euglycemic clamp technique), peak oxygen consumption, blood pressure, plasma lipids, C-reactive protein as well as fasting glucose and insulin. VAT levels for both methods significantly decreased after the weight loss intervention. Furthermore, no differences in VAT levels between both methods were observed before (88.0 ± 25.5 vs. 83.8 ± 22.0 cm(2)) and after (76.8 ± 27.8 vs. 73.6 ± 23.2 cm(2)) the weight loss intervention. In addition, the percent change in VAT levels after the weight loss intervention was similar between both methods (-13.0 ± 16.5 vs. -12.5 ± 12.6%). Moreover, similar relationships were observed between both measures of VAT with cardiometabolic risk factors before and after the weight loss intervention. Finally, results from the logistic regression analysis consistently showed that fat mass and lean body mass were independent predictors of pre- and post-VAT levels for both methods in our cohort. In conclusion, estimated visceral fat levels using the Bertin index may be able to trace variations of VAT after weight loss. This index also shows comparable relationships with cardiometabolic risk factors when compared to VAT measured using CT scan.
本研究旨在探讨使用双能 X 射线吸收仪 (DXA) 获得的 Bertin 指数估算的内脏脂肪组织 (VAT) 与减肥计划前后心血管代谢风险因素的关系，并将其与 CT 扫描测量的 VAT 进行比较。本分析的研究人群包括 92 名非糖尿病超重和肥胖绝经后久坐不动的女性（年龄：58.1 ± 4.7 岁，BMI：31.8 ± 4.2 kg/m²），她们参与了一项减肥干预措施，包括热量限制饮食加或不加阻力训练（RT）。我们测量了（i）使用 CT 扫描测量的 VAT，（ii）使用 DXA 测量的身体成分（并从中计算出 Bertin 指数），（iii）心血管代谢风险因素，如胰岛素敏感性（使用高胰岛素-正常血糖钳夹技术）、峰值耗氧量、血压、血浆脂质、C-反应蛋白以及空腹血糖和胰岛素。减肥干预后，两种方法测量的 VAT 水平均显著降低。此外，减肥干预前后两种方法测量的 VAT 水平无差异（分别为 88.0 ± 25.5 与 83.8 ± 22.0 cm²）。此外，减肥干预后两种方法的 VAT 水平变化百分比相似（分别为-13.0 ± 16.5 与-12.5 ± 12.6%）。此外，减肥干预前后，两种方法测量的 VAT 与心血管代谢风险因素之间也存在相似的关系。最后，逻辑回归分析的结果一致表明，在我们的队列中，脂肪量和瘦体量是两种方法测量的 VAT 前后水平的独立预测因子。总之，使用 Bertin 指数估算的内脏脂肪水平可能能够追踪减肥后 VAT 的变化。与 CT 扫描测量的 VAT 相比，该指数与心血管代谢风险因素也具有相似的关系。
