Rassler Beate, Marx Grit, Hallebach Stephanie, Kalischewski Petra, Baumann Irene
Carl Ludwig Institute of Physiology, University of Leipzig, 04103 Leipzig, Germany.
Autoimmune Dis. 2011;2011:808607. doi: 10.4061/2011/808607. Epub 2011 Jul 7.
Myasthenia gravis (MG) is characterized by reduced muscle endurance and is often accompanied by respiratory complications. Improvement of respiratory function is therefore an important objective in MG therapy. A previous study demonstrated that respiratory muscle endurance training (RMET) over four weeks increased respiratory muscle endurance of MG patients to about 200% of baseline. The purpose of the present study was to establish an appropriate maintenance training and to test its effects over four months. Ten patients with mild to moderate MG participated in this study. During the first month, they performed five training sessions per week. For the following 3 months, training frequency was reduced to five sessions per two weeks. Myasthenia score, lung function, and respiratory endurance were determined prior to training, after the first month, and after 4 months. Myasthenia score improved from 0.71 ± 0.1 to 0.56 ± 0.1 (P = 0.007). Respiratory endurance time increased from 6.1 ± 0.8 to 20.3 ± 3.0 min (P < 0.001). In conclusion, this RMET maintenance program is feasible and is significantly beneficial for MG patients.
重症肌无力（MG）的特征是肌肉耐力下降，且常伴有呼吸并发症。因此，改善呼吸功能是MG治疗的一个重要目标。先前的一项研究表明，为期四周的呼吸肌耐力训练（RMET）可使MG患者的呼吸肌耐力提高至基线水平的约200%。本研究的目的是确定合适的维持训练方法，并测试其在四个月内的效果。10例轻至中度MG患者参与了本研究。在第一个月，他们每周进行5次训练。在接下来的3个月中，训练频率降至每两周5次。在训练前、第一个月后和4个月后测定肌无力评分、肺功能和呼吸耐力。肌无力评分从0.71±0.1改善至0.56±0.1（P = 0.007）。呼吸耐力时间从6.1±0.8分钟增加至20.3±3.0分钟（P < 0.001）。总之，这种RMET维持方案是可行的，对MG患者有显著益处。
