在手性aristolochene 合酶催化中模板效应对消除反应和环化反应的影响
Templating effects in aristolochene synthase catalysis: elimination versus cyclisation.
机构信息
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom.
出版信息
Org Biomol Chem. 2011 Oct 21;9(20):6920-3. doi: 10.1039/c1ob06184d. Epub 2011 Aug 25.
PMID:21870004
Abstract
Analysis of the products generated by mutants of aristolochene synthase from P. roqueforti (PR-AS) revealed the prominent structural role played by the aliphatic residue Leu 108 in maintaining the productive conformation of farnesyl diphosphate to ensure C1-C10 (σ-bond) ring-closure and hence (+)-aristolochene production.
摘要
对罗伊氏乳杆菌（P. roqueforti）aristolochene 合酶突变体产生的产物进行分析，揭示了脂族残基亮氨酸 108 在维持法呢基二磷酸的生产构象以确保 C1-C10（σ键）环合以及因此（+）-aristolochene 产生方面所起的重要结构作用。
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