[急性冠状动脉综合征患者基质Gla蛋白基因的等位基因多态性频率]
[The frequency of allelic polymorphism of matrix Gla-protein gene in acute coronary syndrome patients].
作者信息
Harbuzova V Iu, Hur'ianova V L, Parkhomenko O M, Dosenko V Ie, Ataman O V
出版信息
Fiziol Zh (1994). 2011;57(3):16-24.
Allelic polymorphisms of matrix Gla protein (MGP) gene were determinated in 115 patients with acute coronary syndrome (ACS) and in 110 practically healthy people. It was shown that interrelation of major homozygotes, heterozygotes and minor homozygotes by T-138-->C MGP promoter polymorphism in patients with ACS were 59.8%, 32.7%, 7.5% and in control 58.7%, 36.7%, 4.6% (P>0.05 by X2-test); by G-7-->A polymorphism: 42.1%, 45.6%, 12.3% and 41.8%, 54.5%, 3.6% correspondingly (P<0.05); and by Thr83Ala exon 4 polymorphism: 42.6%, 43.5%, 13.9% compared to 43.9%, 45.9%, 10.2% in control (P>0.05). The obtained data show that MGP A/A variant of MGP promoter G-7-->A polymorphism is a risk factor of ACS in Ukrainian population. These data indicate also that the intensity of calcification influences atherosclerotic injury of coronary artery.
在115例急性冠状动脉综合征（ACS）患者和110例实际健康人群中测定了基质Gla蛋白（MGP）基因的等位基因多态性。结果显示，ACS患者中MGP启动子T-138→C多态性的主要纯合子、杂合子和次要纯合子的比例分别为59.8%、32.7%、7.5%，对照组分别为58.7%、36.7%、4.6%（χ²检验P>0.05）；G-7→A多态性的比例分别为42.1%、45.6%、12.3%和41.8%、54.5%、3.6%（P<0.05）；外显子4 Thr83Ala多态性的比例分别为42.6%、43.5%、13.9%，对照组分别为43.9%、45.9%、10.2%（P>0.05）。所得数据表明，MGP启动子G-7→A多态性的MGP A/A变体是乌克兰人群中ACS的一个危险因素。这些数据还表明钙化强度影响冠状动脉的动脉粥样硬化损伤。
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