Department of Neurosurgery, Geisinger, Danville, PA, United States of America.
Department of Neurosurgery, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany.
PLoS One. 2020 Jun 25;15(6):e0235122. doi: 10.1371/journal.pone.0235122. eCollection 2020.
The MGP single nucleotide polymorphism (SNP) rs1800801 has previously been associated with recurrent ischemic stroke in a Spanish cohort. Here, we tested for association of this SNP with ischemic stroke recurrence in a North American Caucasian cohort. Acute ischemic stroke patients admitted between 10/2009 and 12/2016 at three hospitals within a large healthcare system in the northeastern United States that were enrolled in a healthcare system-wide exome sequencing program were retrospectively reviewed. Patients with recurrent stroke within 1 year after index event were compared to those without recurrence. Of 9,348 suspected acute ischemic strokes admitted between 10/2009 and 12/2016, 1,727 (18.5%) enrolled in the exome-sequencing program. Among those, 1,068 patients had exome sequencing completed and were eligible for inclusion. Recurrent stroke within the first year of stroke was observed in 79 patients (7.4%). In multivariable analysis, stroke prior to the index stroke (OR 9.694, 95% CI 5.793-16.224, p ≤ 0.001), pro-coagulant status (OR = 3.563, 95% CI 1.504-8.443, p = 0.004) and the AA genotype of SNP rs1800801 (OR = 2.408, 95% CI 1.079-4.389, p = 0.004) were independently associated with recurrent stroke within the first year. The AA genotype of the MGP SNP rs1800801 is associated with recurrence within the first year after ischemic stroke in North American Caucasians. Study of stroke subtypes and additional populations will be required to determine if incorporation of allelic status at this SNP into current risk scores improves prediction of recurrent ischemic stroke.
MGP 单核苷酸多态性（SNP）rs1800801 先前与西班牙队列中的复发性缺血性卒中相关。在此，我们在北美白种人群体中检测了该 SNP 与缺血性卒中复发的相关性。在东北部美国一个大型医疗保健系统内的三家医院中，2009 年 10 月至 2016 年 12 月期间，对在全系统外显子测序计划中登记的急性缺血性卒中患者进行了回顾性审查。将在索引事件后 1 年内发生复发性卒中的患者与未发生复发的患者进行了比较。在 2009 年 10 月至 2016 年 12 月期间，9348 例疑似急性缺血性卒中患者中，有 1727 例（18.5%）登记参加了外显子组测序计划。其中，有 1068 例患者完成了外显子组测序，符合纳入条件。在卒中后的第一年中观察到 79 例患者发生了复发性卒中（7.4%）。在多变量分析中，指数性卒中之前的卒中（OR 9.694，95%CI 5.793-16.224，p≤0.001）、促凝状态（OR=3.563，95%CI 1.504-8.443，p=0.004）和 SNP rs1800801 的 AA 基因型（OR=2.408，95%CI 1.079-4.389，p=0.004）与卒中后第一年的复发性卒中独立相关。在北美白种人群中，MGP SNP rs1800801 的 AA 基因型与缺血性卒中后第一年的复发相关。需要对卒中亚型和其他人群进行研究，以确定在当前风险评分中纳入该 SNP 的等位基因状态是否能提高复发性缺血性卒中的预测能力。
