Division of Obstetrics and Gynecology, General Teaching Hospital Korneuburg, Austria.
Gynecol Endocrinol. 2012 Mar;28(3):203-7. doi: 10.3109/09513590.2011.593671. Epub 2011 Aug 26.
To evaluate the effect of red clover isoflavone supplementation over vasomotor and overall menopausal symptoms in postmenopausal women.
One hundred and nine postmenopausal women aged 40 or more were assigned to randomly receive either two daily capsules of the active compound (80 mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Daily hot flush and night sweat frequency and overall menopausal symptom intensity (Kupperman Index) were measured at baseline, 90, 97 and 187 days.
Daily hot flush/night sweat frequency and Kupperman Index values were similar in both studied groups at baseline. All indices significantly decreased after red clover phase in Group A, corresponding, respectively to a 73.5%, 72.2% and 75.4% average decrement. These decrements were significantly higher than those observed for Group B after placebo phase (8.2%, 0.9% and 6.7% respectively). In Group A, after washout and placebo phases all values significantly increased. In Group B, all indices remained similar after placebo and washout phases, however significantly dropping after red clover treatment. These values were also significantly lower than those observed in Group A after placebo phase. No side effects were encountered after treatment with the active compound or placebo.
Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women.
评估红车轴草异黄酮补充剂对绝经后妇女血管舒缩和整体绝经症状的影响。
将 109 名年龄在 40 岁及以上的绝经后妇女随机分为两组，每天服用 2 粒活性化合物（80 毫克红车轴草异黄酮，A 组）或外观相同的安慰剂（B 组），持续 90 天。在 7 天洗脱期后，药物交叉并再服用 90 天。在基线、90 天、97 天和 187 天测量每日潮热和夜间盗汗频率以及整体绝经症状强度（库珀曼指数）。
在基线时，两组研究对象的每日潮热/夜间盗汗频率和库珀曼指数值相似。A 组在红车轴草阶段后所有指标均显著下降，分别对应平均下降 73.5%、72.2%和 75.4%。这些下降明显高于 B 组在安慰剂阶段后的下降（分别为 8.2%、0.9%和 6.7%）。在 A 组中，洗脱期和安慰剂期后所有值均显著增加。在 B 组中，安慰剂和洗脱期后所有指数均相似，但在红车轴草治疗后显著下降。这些值也明显低于 B 组在安慰剂阶段后的值。在服用活性化合物或安慰剂后，未发现不良反应。
与安慰剂相比，红车轴草异黄酮补充剂更能有效减少绝经后妇女每日血管舒缩频率和整体绝经强度。
