Division of Obstetrics and Gynecology General Teaching Hospital Korneuburg, Austria.
Maturitas. 2010 Mar;65(3):258-61. doi: 10.1016/j.maturitas.2009.10.014. Epub 2009 Nov 30.
To evaluate the effect of isoflavones derived from red clover extracts (MF11RCE) over anxiety and depressive symptoms among postmenopausal women.
One hundred and nine postmenopausal women aged 40 or more were randomly assigned to receive two daily capsules of MF11RCE (80mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Anxiety and depressive symptoms were measured at baseline, 90 and 187 days with the Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS).
After receiving the MF11RCE compound the total HADS (anxiety and depression subscale scores also) and the total SDS scores decreased significantly. This effect was equivalent to a 76.9% reduction in the total HADS score (76% for anxiety and 78.3% for depression) and an 80.6% reduction in the total SDS score. After placebo, total HADS (anxiety and depression subscale also) and total SDS scores also decreased significantly in comparison to baseline but only equivalent to an average 21.7% decline.
Red clover derived isoflavones (MF11RCE) were effective in reducing depressive and anxiety symptoms among postmenopausal women.
评估红车轴草提取物异黄酮（MF11RCE）对绝经后妇女焦虑和抑郁症状的影响。
109 名年龄在 40 岁及以上的绝经后妇女被随机分为两组，每天服用 2 粒 MF11RCE（80mg 红车轴草异黄酮，A 组）或外观相同的安慰剂（B 组），为期 90 天。经过 7 天的洗脱期后，药物交叉服用 90 天。采用汉密尔顿焦虑量表（HADS）和 Zung 氏抑郁自评量表（SDS）在基线、90 天和 187 天测量焦虑和抑郁症状。
服用 MF11RCE 后，HADS 总分（焦虑和抑郁亚量表得分也）和 SDS 总分显著下降。这种效果相当于 HADS 总分降低 76.9%（焦虑降低 76%，抑郁降低 78.3%）和 SDS 总分降低 80.6%。服用安慰剂后，HADS 总分（焦虑和抑郁亚量表也）和 SDS 总分与基线相比也显著下降，但仅相当于平均下降 21.7%。
红车轴草异黄酮（MF11RCE）可有效减轻绝经后妇女的抑郁和焦虑症状。
