Division of Epidemiology, Human Genetics and Environmental Sciences, Brownsville Regional Campus, The University of Texas School of Public Health, Brownsville, TX, USA.
Biochem Biophys Res Commun. 2011 Sep 9;412(4):728-31. doi: 10.1016/j.bbrc.2011.08.041. Epub 2011 Aug 17.
Previous studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes.
Expression of ATP6V1H in peripheral blood was compared pre and post development of diabetes in nine individuals.
Considerable variation of ATP6V1H mRNA levels was observed between different individuals. However, within each individual the decrease in expression of ATP6V1H with the development of diabetes was highly statistically significant.
ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity.
先前在小鼠和人类中的研究观察到与 2 型糖尿病相关的 ATP6V1H 基因表达下调。本研究前瞻性地观察了显性糖尿病前后 ATP6V1H 表达的变化。
比较了 9 个人在发生糖尿病前后外周血中 ATP6V1H 的表达。
不同个体之间观察到 ATP6V1H mRNA 水平的显著差异。然而,在每个个体中,随着糖尿病的发展,ATP6V1H 的表达下降具有高度统计学意义。
ATP6V1H 可能代表了一种关键的分子机制,通过对液泡型 ATP 酶活性的重要调节作用,参与 2 型糖尿病及其并发症的发生。