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1
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.与阿尔茨海默病相关的亚稳定亚蛋白组的蛋白质平衡。
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26.
2
The Ubiquitin System in Alzheimer's Disease.阿尔茨海默病中的泛素系统。
Adv Exp Med Biol. 2020;1233:195-221. doi: 10.1007/978-3-030-38266-7_8.
3
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.健康大脑中的蛋白质稳态特征再现了阿尔茨海默病对组织的易损性。
Sci Adv. 2016 Aug 10;2(8):e1600947. doi: 10.1126/sciadv.1600947. eCollection 2016 Aug.
4
Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease.阿尔茨海默病中 tau 积累的泛素蛋白酶体系统紊乱。
Neurobiol Aging. 2021 Mar;99:79-85. doi: 10.1016/j.neurobiolaging.2020.11.015. Epub 2020 Dec 8.
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Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.在阿尔茨海默病神经原纤维缠结中，泛素、热休克蛋白27、帕金森蛋白和α-突触核蛋白通过γ-谷氨酰-ε-赖氨酸键发生交联。
FASEB J. 2004 Jul;18(10):1135-7. doi: 10.1096/fj.04-1493fje. Epub 2004 May 7.
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A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.阿尔茨海默病的转录特征与有聚集风险的亚蛋白质组的亚稳定性有关。
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.
7
The role of protein clearance mechanisms in organismal ageing and age-related diseases.蛋白质清除机制在机体衰老和与年龄相关疾病中的作用。
Nat Commun. 2014 Dec 8;5:5659. doi: 10.1038/ncomms6659.
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Protein aggregation in Alzheimer's disease: Aβ and τ and their potential roles in the pathogenesis of AD.阿尔茨海默病中的蛋白质聚集：淀粉样β蛋白和τ蛋白及其在阿尔茨海默病发病机制中的潜在作用。
Acta Neuropathol. 2015 Feb;129(2):163-5. doi: 10.1007/s00401-015-1387-2.
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Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.阿尔茨海默病死后大脑中乙酰化和总组蛋白水平升高。
Neurobiol Dis. 2015 Feb;74:281-94. doi: 10.1016/j.nbd.2014.11.023. Epub 2014 Dec 5.
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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.可溶性纤维前体tau蛋白和β-淀粉样蛋白在早期人类阿尔茨海默病中出现，并与疾病进展和认知衰退相关。
Acta Neuropathol. 2016 Dec;132(6):875-895. doi: 10.1007/s00401-016-1632-3. Epub 2016 Oct 21.
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Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer's disease mice.发现一种可改善阿尔茨海默病小鼠记忆力的小分子分泌型簇集蛋白增强剂。
NPJ Drug Discov. 2025;2(1):7. doi: 10.1038/s44386-025-00009-2. Epub 2025 May 2.
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Tetraploidy in normal tissues and diseases: mechanisms and consequences.正常组织和疾病中的四倍体：机制与后果
Chromosoma. 2025 Mar 21;134(1):3. doi: 10.1007/s00412-025-00829-1.
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Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.多队列脑脊液蛋白质组学确定了阿尔茨海默病连续体中的强大分子特征。
Neuron. 2025 May 7;113(9):1363-1379.e9. doi: 10.1016/j.neuron.2025.02.014. Epub 2025 Mar 14.
4
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription.星形胶质细胞 tau 沉积与进行性核上性麻痹中 MAPT 转录的失调有关。
Acta Neuropathol Commun. 2024 Aug 14;12(1):132. doi: 10.1186/s40478-024-01844-6.
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Diverging co-translational protein complex assembly pathways are governed by interface energy distribution.分歧的共翻译蛋白质复合物组装途径由界面能量分布控制。
Nat Commun. 2024 Mar 25;15(1):2638. doi: 10.1038/s41467-024-46881-w.
6
Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics.内耳神经生物学、健康与疾病中的多酚：从基础到临床。
Medicina (Kaunas). 2023 Nov 20;59(11):2045. doi: 10.3390/medicina59112045.
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Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.通过固态纳米孔对错误折叠蛋白寡聚物进行多重数字特征分析。
J Am Chem Soc. 2023 Nov 29;145(47):25776-25788. doi: 10.1021/jacs.3c09335. Epub 2023 Nov 16.
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Mechanisms and pathology of protein misfolding and aggregation.蛋白质错误折叠和聚集的机制和病理学。
Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8.
9
Protein nanocondensates: the next frontier.蛋白质纳米凝聚物：下一个前沿领域。
Biophys Rev. 2023 Aug 9;15(4):515-530. doi: 10.1007/s12551-023-01105-1. eCollection 2023 Aug.
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Protein Aggregates and Aggrephagy in Myopathies.蛋白聚集物和肌病中的聚集物吞噬
Int J Mol Sci. 2023 May 8;24(9):8456. doi: 10.3390/ijms24098456.
本文引用的文献
1
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.脊髓运动神经元蛋白过饱和模式与 ALS 中的包涵体形成有关。
Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10.
2
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.基因组规模的网络将神经退行性疾病基因与α-突触核蛋白通过特定的分子途径联系起来。
Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.
3
Molecular Genetics of Neurodegenerative Dementias.神经退行性痴呆的分子遗传学
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):a023705. doi: 10.1101/cshperspect.a023705.
4
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.健康大脑中的蛋白质稳态特征再现了阿尔茨海默病对组织的易损性。
Sci Adv. 2016 Aug 10;2(8):e1600947. doi: 10.1126/sciadv.1600947. eCollection 2016 Aug.
5
Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.泛素连接蛋白作为伴侣蛋白并对线粒体膜蛋白进行分类以便降解。
Mol Cell. 2016 Jul 7;63(1):21-33. doi: 10.1016/j.molcel.2016.05.020. Epub 2016 Jun 23.
6
Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond.阿尔茨海默病相关的遗传变异：全基因组关联研究及其他研究的证据。
Lancet Neurol. 2016 Jul;15(8):857-868. doi: 10.1016/S1474-4422(16)00127-7.
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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.PSEN2/γ-分泌酶的受限定位决定底物特异性并产生细胞内Aβ池。
Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9.
8
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.溶酶体酸化紊乱——V-ATP酶在衰老和神经退行性疾病中的新作用
Ageing Res Rev. 2016 Dec;32:75-88. doi: 10.1016/j.arr.2016.05.004. Epub 2016 May 16.
9
A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.阿尔茨海默病的转录特征与有聚集风险的亚蛋白质组的亚稳定性有关。
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.
10
The amyloid hypothesis of Alzheimer's disease at 25 years.阿尔茨海默病淀粉样蛋白假说25年回顾
EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun.
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