Department of Obstetrics and Gynecology, Christchurch School of Medicine, University of Otago, Christchurch, New Zealand.
Am J Obstet Gynecol. 2011 Nov;205(5):478.e1-7. doi: 10.1016/j.ajog.2011.06.069. Epub 2011 Jun 25.
The purpose of this study was to review the outcome of conservatively managed cervical intraepithelial neoplasia (CIN) 2 in women <25 years old.
This was a retrospective review that included women who were <25 years old with biopsy proven CIN2 between 2005 and 2009. Analysis was performed that compared women who had immediate treatment with women whose treatment was deferred >4 months. The primary outcome measure was spontaneous regression of CIN2. Secondary outcomes were treatment rates and loss to follow-up evaluation.
Of the 452 women who were identified, 256 women (57%) received immediate treatment; 157 women (35%) met the definition for conservative management, and 39 women (9%) had unknown subsequent management. Of the 157 women who were managed conservatively, 98 women (62%) showed spontaneous regression, with a median of 8 months observation. No conservatively managed women progressed to cancer.
Based on the 62% regression rate in this study, routine treatment may not be necessary for all women with CIN2 who are <25 years old.
本研究旨在回顾年轻女性（<25 岁）中保守治疗的宫颈上皮内瘤变（CIN）2 的结局。
这是一项回顾性研究，纳入了 2005 年至 2009 年间活检证实为 CIN2 的年龄<25 岁的女性。分析比较了立即治疗和治疗延迟>4 个月的女性。主要结局指标是 CIN2 的自然消退。次要结局指标为治疗率和失访评估。
在 452 名女性中，256 名（57%）接受了立即治疗；157 名（35%）符合保守治疗标准，39 名（9%）后续管理情况不明。在 157 名接受保守治疗的女性中，98 名（62%）出现自发消退，中位观察时间为 8 个月。没有保守治疗的女性进展为癌症。
根据本研究的 62%的消退率，对于所有<25 岁的 CIN2 年轻女性，常规治疗可能并非必需。
