Government Medical College and Hospital, Department of Ophthalmology, Sector 32B, Chandigarh, India.
Turk J Ophthalmol. 2020 Apr 29;50(2):75-81. doi: 10.4274/tjo.galenos.2019.29000.
The use of benzalkonium chloride (BAC)-preserved medications is associated with ocular surface disease (OSD) that can negatively affect quality of life (QoL) in glaucoma patients. This study aimed to compare QoL and correlate it with OSD in glaucoma patients receiving BAC-preserved and BAC-free travoprost.
A total of 110 subjects were divided into 3 groups: 40 primary open-angle glaucoma (POAG) patients using BAC-preserved travoprost, 40 POAG patients using BAC-free travoprost, and 30 age-matched controls. All patients were assessed using a single interviewer-administered format of the Ocular Surface Disease index (OSDI) and Glaucoma Quality of Life-15 (GQL-15) questionnaires.
Mean GQL-15 score in the BAC group was significantly higher than in the BAC-free group (24.71±7.42 vs. 17.58±3.06; p<0.05). The mean difference in GQL-15 scores between controls and the BAC-free group (1.24) was insignificant (p>0.05). There was a strong positive correlation between OSDI scores and GQL-15 scores in all the groups (r values: BAC: 0.63, BAC-free: 0.23, controls: 0.29), with higher OSDI scores (severe OSD) associated with higher GQL-15 scores (worse QoL). Cronbach's alpha was 0.84 for GQL-15 and 0.75 for OSDI.
BAC-preserved travoprost leads to higher OSDI scores, which correlate strongly with poor QoL scores as compared to BAC-free travoprost. The use of BAC-free formulations should be encouraged to reduce the onset or worsening of OSD and impaired QoL in glaucoma patients.
苯扎氯铵（BAC）保存药物的使用与眼表疾病（OSD）相关，这可能会对青光眼患者的生活质量（QoL）产生负面影响。本研究旨在比较接受 BAC 保存和 BAC 免费曲伏前列素治疗的青光眼患者的 QoL，并将其与 OSD 相关联。
共有 110 名受试者分为 3 组：40 名使用 BAC 保存的曲伏前列素的原发性开角型青光眼（POAG）患者，40 名使用 BAC 免费的曲伏前列素的 POAG 患者和 30 名年龄匹配的对照组。所有患者均使用由单一访谈者管理的眼表疾病指数（OSDI）和青光眼生活质量-15（GQL-15）问卷进行评估。
BAC 组的平均 GQL-15 评分明显高于 BAC 免费组（24.71±7.42 vs. 17.58±3.06；p<0.05）。对照组与 BAC 免费组之间的 GQL-15 评分差异平均值（1.24）无统计学意义（p>0.05）。在所有组中，OSDI 评分与 GQL-15 评分之间均存在强正相关（r 值：BAC：0.63，BAC 免费：0.23，对照组：0.29），较高的 OSDI 评分（严重的 OSD）与较高的 GQL-15 评分（较差的 QoL）相关。GQL-15 的 Cronbach's alpha 为 0.84，OSDI 为 0.75。
与 BAC 免费的曲伏前列素相比，BAC 保存的曲伏前列素导致更高的 OSDI 评分，与较差的 QoL 评分密切相关。应鼓励使用 BAC 免费制剂，以减少青光眼患者 OSD 和受损 QoL 的发生或恶化。
