Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School, Singapore.
Neuroimage. 2012 Jan 16;59(2):1745-51. doi: 10.1016/j.neuroimage.2011.08.026. Epub 2011 Aug 18.
Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks.
睡眠剥夺（SD）会改变与注意力、记忆和执行功能相关的外在、任务相关的 fMRI 信号。然而，其对默认模式网络（DMN）内固有低频连接及其相关的反相关网络（ACN）的影响尚未得到很好的描述。我们研究了 SD 对 DMN 内功能连接以及 DMN-ACN 反相关的影响，这两种影响都是在静息状态和视觉注意力任务（VAT）期间进行的。26 名健康参与者接受了两次 fMRI 检查：一次是在正常的夜间睡眠后处于清醒休息状态（RW），一次是在大约 24 小时的总 SD 后。使用基于种子的方法来检查每个状态中不同节点之间的低频 fMRI 信号的成对相关性。SD 与 DMN 功能连接和 DMN-ACN 反相关的显著选择性降低有关。这与静息状态和 VAT 分析一致，表明 SD 诱导了这些网络内和网络间固有连接的稳健改变。
