Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro 2, I-53100 Siena, Italy.
Drug Discov Today. 2012 Jan;17(1-2):81-8. doi: 10.1016/j.drudis.2011.08.004. Epub 2011 Aug 18.
LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.
LIM 激酶（LIMK）通过招募许多大分子伴侣来发挥其功能，这些伴侣可以以正向或负向的方式调节 LIMK 的活性。除了在人和动物细胞和组织中与 LIMK 相互作用的蛋白质外，最近的数据还表明，HIV-1 病毒蛋白也会影响 LIMK 的活性。这些结果为基于抑制 LIMK 介导的肌动蛋白丝解聚蛋白失活和随后的肌动蛋白解聚的 HIV-1 感染治疗提供了新的策略。然而，还需要进一步的努力来阐明病毒干扰 LIMK 活性以及肌动蛋白重塑的正确平衡的机制。
