Glomset J A, Gelb M H, Farnsworth C C
Howard Hughes Medical Institute Laboratory, Department of Medicine, University of Washington, Seattle 98195.
Trends Biochem Sci. 1990 Apr;15(4):139-42. doi: 10.1016/0968-0004(90)90213-u.
Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.
