Blom J H, Ten Kate F J, Schroeder F H, van der Heul R O
Department of Urology, Erasmus University, Rotterdam, The Netherlands.
Urol Res. 1990;18(2):93-9. doi: 10.1007/BF00302467.
At present there are several grading systems for prostatic carcinoma. Most are difficult to reproduce. An objective method of grading seems to be necessary and could make comparisons between various groups of patients easier and grading more reliable. In the present study morphometrically estimated nuclear size and variation in nuclear size are matched with the survival rates of 207 patients who underwent total perineal prostatectomy for cancer. On the basis of morphometrically estimated variation in nuclear size the patients could be divided into two groups with significantly differing survival rates. In this way it was possible to split the group of patients with grade 2 carcinoma (Mostofi's grading system) into two groups of patients with significantly different survival rates. The survival rates in these two groups did not differ significantly from those in the patients with Grade 1 and Grade 3 tumors respectively. The results are discussed in the light of the recent literature on the subject. Morphometry seems to be a valuable tool in grading prostatic cancer.
目前有几种前列腺癌分级系统。大多数分级系统难以重复使用。一种客观的分级方法似乎很有必要，它可以使不同患者组之间的比较更容易，分级更可靠。在本研究中，通过形态测量法估计的细胞核大小和细胞核大小的变化与207例因癌症接受全会阴前列腺切除术患者的生存率相匹配。根据形态测量法估计的细胞核大小变化，患者可分为两组，其生存率有显著差异。通过这种方式，有可能将2级癌患者组（莫斯托菲分级系统）分为两组生存率有显著差异的患者。这两组的生存率分别与1级和3级肿瘤患者的生存率无显著差异。根据最近关于该主题的文献对结果进行了讨论。形态测量法似乎是前列腺癌分级中的一种有价值的工具。
