Schroeder F H, Hop W C, Blom J H, Mostofi F K
Prostate. 1985;7(1):13-20. doi: 10.1002/pros.2990070103.
This work is based on the two previous publications which are concerned with grading prostatic carcinoma. In the present communication the technique of multivariate analysis is applied to quantify the prognostic importance of parameters which were earlier identified as contributing in a significant manner to grading. The results of this analysis are used to construct a scoring system which differentiates five significantly different prognostic groups. When compared to the results of grading, the new system is shown to be superior. The large group of 228 patients with G2 tumors can be split into three groups, each with a significantly different prognosis. The correlation of the scoring system to local tumor extension (pT category) is described. Recommendations for grading of prostatic carcinoma resulting from this work are the following: Only three independent parameters are of significance for grading prostatic cancer: tumor architecture, nuclear anaplasia, and the presence or absence of mitoses. The combination of these parameters in a scoring system identifies five separate prognostically different groups. The separation achieved by this new system is superior to conventional grading and is suggested for grading prostatic cancer.
本研究基于之前两篇关于前列腺癌分级的出版物。在本报告中，多变量分析技术被用于量化先前确定对分级有显著贡献的参数的预后重要性。该分析结果用于构建一个评分系统，该系统区分出五个显著不同的预后组。与分级结果相比，新系统显示出更优。228例G2肿瘤患者的大样本组可分为三组，每组预后显著不同。描述了评分系统与局部肿瘤扩展（pT类别）的相关性。这项工作得出的前列腺癌分级建议如下：对于前列腺癌分级，只有三个独立参数具有重要意义：肿瘤结构、核间变以及有丝分裂的有无。这些参数在一个评分系统中的组合确定了五个不同的预后组。这个新系统实现的区分优于传统分级，建议用于前列腺癌分级。
